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Research

Clinical research is an important part of what we do at C&I. And the reason it’s important is because it enables us to provide our service users with the latest, most innovative techniques available to aid recovery.
 
If you use our services you will find that our treatments are among the best in the country and are sometimes at the forefront of international thinking and development. To help us ensure we are leading the field, we collaborate with other organisations that are also active in research, expanding our knowledge in psychiatry, psychology, counselling and nursing.
 
You can find a list of studies currently running at the Trust below.

Our commitment

We are committed to giving our service users the opportunity to be involved in research. By partnering with academics from the Faculty of Brain Sciences at University College London (UCL), we are able to benefit from and contribute to world class research. 
 
For example in a recent high profile project led by UCL called Strategies for Relatives, research showed that if a family member is given eight brief sessions with a psychologist soon after a relative is diagnosed with dementia, their likelihood of developing depression is reduced seven fold. As we took part in this research, we are now using this model of care across our Trust today. 
 
 

C&I Research Team

 

Studies which run at C&I are supported by a dedicated, multi-disciplinary Research Team located at St Pancras Hospital. The team is funded by North Thames Clinical Research Network, which is part of the National Institute of Health Research (NIHR). The NIHR is the nation’s largest funder of health and care research, and provides the people, facilities and technology that enables research to thrive in the NHS. The team help make research happen across all Divisions at C&I.

 

If you would like to find out more about research at C&I, if you are interested in taking part in a study, or you would like to conduct a research trial of your own, then please contact the Research Team Manager Nick Green by post, email or phone using these details:

Nick Green, Research Team Manager

C&I Research Team
1st Floor, Bloomsbury Building
St Pancras Hospital
4 St Pancras Way, NW1 0PE

Email: nicolas.green@candi.nhs.uk
Tel: 020 3317 7615

Noclor Research Support provide our Research and Development function. Noclor assesses whether a proposed study is acceptable for the Trust to take on. They also ensure that the study will be safe, and that the practices involved are of the highest ethical standard. All studies which run at C&I have been approved by Noclor. They can be contacted at contact.noclor@nhs.net

You can read the Research and Development performance reports available to download from this page.

Current studies at the Trust

These are studies which are currently recruiting participants at the Trust. Click on the title of the study to see an information sheet which gives more detail. 
 

Mental health studies

Brightmind: Brain Image Guided Transcranial Magnetic in Depression A comparison of two different types of Transcranial Magnetic Stimulation (TMS) to treat Treatment Resistant Depression. TMS involves 20 daily sessions delivered over a four to six week period. Recruiting service users diagnosed with Major Depression Disorder that has not improved with two previous antidepressant treatments. Service users can self-refer to the study. 
 
Exploring Unusual Feelings is a questionnaire which takes 30-40 minutes to complete. It is to learn more about experiences that are called ‘depersonalisation’ or ‘dissociation’. These are strange feelings and experiences, which can make people feel numb, unreal, detached, or ‘spaced out’. The study team is interested in knowing if experiences like these are related to others, like having worries about others trying to harm you, or hearing or seeing things that other people cannot see or hear. Recruiting service users over 16 with a diagnosis of non-affective psychosis.
 
Genetic Links to Anxiety and Depression (GLAD)  The GLAD Study will explore genetic risk factors in individuals who have suffered with, or been diagnosed with, depression and/or anxiety. Participants complete an online questionnaire, and if eligible, are sent a kit to return a saliva sample by post.  Recruiting staff and service users who have experienced anxiety or depression. 
 
National Centre for Mental Health (NCMH) is collecting information and samples to create an anonymised database to be used for genetic, biological and psychological and clinical research into mental disorders. Participants complete an assessment and give a blood sample. Recruiting service users aged over 18 diagnosed with a serious mental illness. 
 
Open Dialogue: Development and Evaluation of a Social Network Intervention for Severe Mental Illness (ODDESSI)  Open Dialogue (OD) is an alternative way of supporting people during and after a crisis. The study will compare the clinical effectiveness and cost-effectiveness of Open Dialogue in preventing relapse, compared with current NHS care. Recruiting service users in crisis in North Islington area.
 
Prevalence of neuronal cell surface antibodies in patients with psychotic illness (PPiP2)  The study aims to understand if some causes of psychosis are caused by immune system problems in some people.
Recruiting service users aged 18 to 70 who are experiencing a first episode of psychosis, or relapse of psychotic illness 
 
Probing social exchanges: a computational neuroscience approach to understanding BPD and ASPD  An investigation of social interaction styles/behaviours and personality/characteristics in people with Borderline Personality Disorder (BPD) or Anti-Social Personality Disorder (ASPD).
Recruiting service users with a BPD or ASPD diagnosis.
 
Probing social exchanges: a computational neuroscience approach to understanding Major depression Disorder (MDD)   An investigation of social interaction styles/behaviours and personality/characteristics in people with Major Depression Disorder (MDD).
Recruiting service users with MDD diagnosis. 
 
Research into Antipsychotic Discontinuation and Reduction (RADAR)  A comparison of the strategy of gradual antipsychotic reduction and possible discontinuation with maintenance treatment in people with schizophrenia or who have recurrent psychotic episodes.
Recruiting service users with a diagnosis of schizophrenia, schizoaffective disorder, delusional disorder or other nonaffective psychosis. 
 
Relapse Evaluation using Smartphone Technology (REST)  A feasibility study to determine whether it’s possible to predict relapse in serious mental illness using smartphone data. 
Recruiting service users who have a diagnosis of schizophrenia, bipolar disorder, or non-organic psychosis; have been in contact with crisis team OR been an inpatient in past 12 weeks; and own a smartphone. 
 
Understanding intention and agency in psychosis  An examination of whether there are differences between participants with and without psychosis in their ability to correctly detect if they are partnered with a real human or an AI in online social experimental tasks. Recruiting service users aged 18 to 65 who have a psychosis diagnosis. 
 
Understanding the experience of psychosis  A qualitative investigation of the lived experience and phenomenology of psychosis. Recruiting service users who have a psychosis diagnosis.
 

Dementia studies

Clinical trial of Mirtazapine versus placebo in the treatment of agitation for people with dementia (SYMBAD) Service users who have Alzheimer’s Dementia or mixed dementia plus agitation, who have not responded to behavioural intervention.
Recruiting service users and carers (paid or unpaid). 
 
Evaluating the validity of the tool used by Islington Dementia Navigators to assess risk (RAISe)  A study appraising the risk assessment tool used by Dementia Nagivators in Islington. Recruiting service users newly referred to Dementia Navigators, who live in their own home. 
 
Problem Adaptation Therapy for Depression in Dementia (PATHFINDER) An intervention which teaches problem-solving skills, combined with environmental adaptation tools, to improve function and facilitate engagement in pleasurable activities for people with Alzheimer’s Disease and depression. The study will compare a group of people who receive the intervention with people who receive normal care.
Recruiting people with a diagnosis of, or probable, mild to moderate Alzheimer’s Disease and clinically significant depression, and a family carer who is able to act as co-therapist for the intervention. 
 
Nutrition, hydration and care for people with dementia at the end of life  How can we best support family carers (Nutri-Dem)?  A qualitative study exploring what carers understand about eating, drinking and swallowing in the later stages of dementia, and how they manage this.
Recruiting service users with any type of dementia, and family or friend carers of people with any type of dementia but who are at the end of life.
 
You can find out more about these, and other dementia studies running elsewhere in London and across the UK, at Join Dementia Research
 

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